Downlink Noncoherent Cooperation without Transmitter Phase Alignment

Multicell joint processing can mitigate inter-cell interference and thereby increase the spectral efficiency of cellular systems. Most previous work has assumed phase-aligned (coherent) transmissions from different base transceiver stations (BTSs), which is difficult to achieve in practice. In this work, a noncoherent cooperative transmission scheme for the downlink is studied, which does not require phase alignment. The focus is on jointly serving two users in adjacent cells sharing the same resource block. The two BTSs partially share their messages through a backhaul link, and each BTS transmits a superposition of two codewords, one for each receiver. Each receiver decodes its own message, and treats the signals for the other receiver as background noise. With narrowband transmissions the achievable rate region and maximum achievable weighted sum rate are characterized by optimizing the power allocation (and the beamforming vectors in the case of multiple transmit antennas) at each BTS between its two codewords. For a wideband (multicarrier) system, a dual formulation of the optimal power allocation problem across sub-carriers is presented, which can be efficiently solved by numerical methods. Results show that the proposed cooperation scheme can improve the sum rate substantially in the low to moderate signal-to-noise ratio (SNR) range.Comment: 30 pages, 6 figures, submitted to IEEE Transactions on Wireless Communication

Methods for Learning a User’s Intent Based on Spatial Gestures

This publication describes methods for learning a user’s intent, when the user interacts with multiple computing devices, based on detected spatial gestures. The methods may utilize a machine-learned model with a reinforcement-learning framework trained to classify spatial gestures, user state information, and/or device state information detected during a device-to-device interaction, generate predictions relating to the intent of the user, and utilize the predictions to facilitate the device-to-device interaction

Biometric Risk Factors for Angle Closure Progression After Laser Peripheral Iridotomy

IMPORTANCE: Laser peripheral iridotomy (LPI) is the most common primary treatment for primary angle closure disease (PACD). However, there are sparse data guiding the longitudinal care of PAC suspect (PACS) eyes after LPI. OBJECTIVE: To elucidate the anatomic effects of LPI that are associated with a protective outcome against progression from PACS to PAC and acute angle closure (AAC) and to identify biometric factors that predict progression after LPI. DESIGN, SETTING, AND PARTICIPANTS: This was a retrospective analysis of data from the Zhongshan Angle Closure Prevention (ZAP) trial, a study of mainland Chinese people aged 50 to 70 years with bilateral PACS who received LPI in 1 randomly selected eye. Gonioscopy and anterior-segment optical coherence tomography (AS-OCT) imaging were performed 2 weeks after LPI. Progression was defined as the development of PAC or an acute angle closure (AAC) attack. Cohort A included a random mix of treated and untreated eyes, and cohort B included only eyes treated with LPI. Univariable and multivariable Cox regression models were developed to assess biometric risk factors for progression in cohorts A and B. Data were analyzed from January 4 to December 22, 2022. MAIN OUTCOME AND MEASURE: Six-year progression to PAC or AAC. RESULTS: Cohort A included 878 eyes from 878 participants (mean [SD] age, 58.9 [5.0] years; 726 female [82.7%]) of whom 44 experienced progressive disease. In a multivariable analysis, treatment (hazard ratio [HR], 0.67; 95% CI, 0.34-1.33; P = .25) was no longer associated with progression after adjusting for age and trabecular iris space area at 500 μm (TISA at 500 μm) at the 2-week visit. Cohort B included 869 treated eyes from 869 participants (mean [SD] age, 58.9 [5.0] years; 717 female [82.5%]) of whom 19 experienced progressive disease. In multivariable analysis, TISA at 500 μm (HR, 1.33 per 0.01 mm2 smaller; 95% CI, 1.12-1.56; P = .001) and cumulative gonioscopy score (HR, 1.25 per grade smaller; 95% CI, 1.03-1.52; P = .02) at the 2-week visit were associated with progression. Persistent angle narrowing on AS-OCT (TISA at 500 μm ≤0.05 mm2; HR, 9.41; 95% CI, 3.39-26.08; P <.001) or gonioscopy (cumulative score ≤6; HR, 2.80; 95% CI, 1.13-6.93; P =.04) conferred higher risk of progression. CONCLUSIONS AND RELEVANCE: Study results suggest that persistent angle narrowing detected by AS-OCT or cumulative gonioscopy score was predictive of disease progression in PACS eyes after LPI. These findings suggest that AS-OCT and gonioscopy may be performed to identify patients at high risk of developing angle closure who may benefit from closer monitoring despite patent LPI

Mir-382 Promotes Differentiation of Rat Liver Progenitor Cell WB-F344 by Targeting Ezh2

Background/Aims: Liver progenitor cells (LPCs) were considered as a promising hepatocyte source of cell therapy for liver disease due to their self-renewal and differentiation capacities, while little is known about the mechanism of LPC differentiate into hepatocytes. This study aims to explore the effect of miR-382, a member of Dlk1-Dio3 microRNA cluster, during hepatic differentiation from LPCs. Methods: In this study, we used rat liver progenitor cell WB-F344 as LPC cell model and HGF as inducer to simulate the process of LPCs hepatic differentiation, then microRNAs were quantified by qPCR. Next, WB-F344 cell was transfected with miR-382 mimics, then hepatocyte cell trait was characterized by multiple experiments, including that periodic acid schiff staining and cellular uptake and excretion of indocyanine green to evaluate the hepatocellular function, qPCR and Western Blotting analysis to detect the hepatocyte-specific markers (ALB, Ttr, Apo E and AFP) and transmission electron microscopy to observe the hepatocellular morphology. Moreover, Luciferase reporter assay was used to determine whether Ezh2 is the direct target of miR-382. Results: We found that miR-382 increased gradually and was inversely correlated with the potential target, Ezh2, during WB-F344 hepatic differentiation. In addition, functional studies indicated that miR-382 increased the level of hepatocyte-specific genes. Conclusions: This study demonstrates that miR-382 may be a novel regulator of LPCs differentiation by targeting Ezh2

A study assessing the association of glycated hemoglobin a1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of asian ancestry

10.1371/journal.pone.0079767PLoS ONE811-POLN

A Conservative Level Set Approach to Non-Spherical Drop Impact in Three Dimensions

A recently developed conservative level set model, coupled with the Navier-Stokes equations, was invoked to simulate non-spherical droplet impact in three dimensions. The advection term in the conservative level set model was tackled using the traditional central difference scheme on a half-staggered grid. The pressure velocity coupling was decoupled using the projection method. The inhouse code was written in Fortran and was run with the aid of the shared memory parallelism, OpenMP. Before conducting extensive simulations, the model was tested on meshes of varied resolutions and validated against experimental works, with satisfyingly qualitative and quantitative agreement obtained. The model was then employed to predict the impact and splashing dynamics of non-spherical droplets, with the focus on the effect of the aspect ratio. An empirical correlation of the maximum spread factor was proposed. Besides, the number of satellite droplets when splashing occurs was in reasonable agreement with a theoretical model

Combined optimal dispatching of wind-light-fire-storage considering electricity price response and uncertainty of wind and photovoltaic power

The high proportion of renewable energy connected to the power grid puts enormous pressure on the power system for peaking. To reduce the peak-to-valley load difference, reduce the abandoned wind and light rate, and improve the economy of power system peaking, this paper constructs a wind–light–fire-storage joint optimal dispatching model based on electricity price response and uncertainty of wind and photovoltaic power. First, the model adds electricity price response to guide customers to change their electricity consumption habits by adjusting electricity prices at different times, bringing economic benefits to customers while shifting part of the peak load to the trough to achieve the purpose of peak shaving and valley filling; Secondly, considering the impact of wind and photovoltaic output uncertainty on power grid peaking, chance-constrained programming is added to the model, which is based on the simulation method, using the Latin hypercube sampling method, eventually transformed into a mixed integer linear programming model for solution; Finally, simulation is carried out in the modified IEEE30 node system to verify the feasibility and effectiveness of the model

Limited Feedback for Multi-Carrier Beamforming: A Rate-Distortion Approach

Abstract-The achievable rate of a wideband Multi-Input Single-Output channel with multi-carrier transmission is studied with limited feedback of Channel State Information (CSI). The set of sub-channel vectors are assumed to be jointly quantized and relayed back to the transmitter. Given a fixed feedback rate, the performance of an optimal joint quantization scheme can be characterized by the rate-distortion bound. The distortion metric is the average loss in capacity (forward rate) relative to the capacity with perfect channel state information at the transmitter and receiver. The corresponding rate-distortion function gives the forward capacity as a function of feedback rate, and is determined explicitly by casting the minimization of mutual information as an optimal control problem. Numerical results show that when the feedback rate is small, the rate-distortion bound significantly outperforms separate vector quantization of each sub-channel vector. Practical issues, such as quantization codebook design and implementation, are also briefly discussed